Alcohol is a widely used and abused substance that slows down the central nervous system. Its effects often sedate the users, leading to a mood lift and anxiety relief, but accompanied with impaired motor function and cognition. 

Combining alcohol with other depressants can have serious and potentially life-threatening consequences. Depressants such as benzodiazepines, opioids, or even over-the-counter medications like sleep aids or antihistamines can intensify the sedative effects of alcohol. This combination can lead to extreme drowsiness, impaired coordination, slowed heart rate, and suppressed breathing. It is crucial to understand that the combined effect of alcohol and other depressants can result in a dangerous synergistic effect that amplifies the depressant properties, increasing the risk of accidents, respiratory depression, or overdose. To ensure your safety, it is essential to never mix alcohol with other depressants and consult a healthcare professional if you have any concerns about potential interactions.

One of the most effective ways to minimize the likelihood and intensity of a hangover when consuming alcohol is to stay hydrated throughout the drinking session. Alcohol is a diuretic, meaning it increases urine production and can lead to dehydration. Dehydration can exacerbate the symptoms of a hangover, such as headache, fatigue, and dry mouth. To maintain adequate hydration, it is recommended to drink water in between alcoholic beverages. Alternating alcoholic drinks with non-alcoholic options like water, sports drinks, or electrolyte-rich beverages can help replenish fluids and essential minerals lost due to alcohol's dehydrating effects. Additionally, consuming a glass of water before bed after drinking can further aid in rehydration and alleviate potential morning-after discomfort. Remember, staying hydrated is key to reducing the severity of hangovers and promoting overall well-being when consuming alcohol.

Alcohol

Alcohol poisoning is a serious — and sometimes deadly — consequence of consuming large amounts of alcohol in a short period. It is a state in which a high level of alcohol in the body affects the brain, impairing basic life-support functions like heart rate, breathing, and temperature control, eventually leading to coma or death [1].

The liver is particularly vulnerable to alcohol-related harm because it's the primary site of alcohol metabolism. Chronic and heavy alcohol consumption can lead to various liver diseases such as alcoholic hepatitis, cirrhosis, and an increased risk of liver cancer. Alcohol causes liver inflammation and swelling, which over time can result in scarring and loss of function [2].

Long-term alcohol use can lead to physical and psychological dependence. This dependence can result in withdrawal symptoms when alcohol use is suddenly stopped or significantly reduced. Symptoms can range from mild to severe, including anxiety, tremors, hallucinations, and even seizures. Alcohol dependence can also lead to alcohol use disorder (AUD), a chronic relapsing brain disease characterized by compulsive alcohol use, loss of control over alcohol intake, and a negative emotional state when not using [3].

Research has shown that alcohol consumption can increase the risk of several types of cancer, including mouth, throat, esophagus, liver, colon, and breast cancer. The risk increases with the amount of alcohol consumed. It is believed that alcohol's carcinogenic effect is partly due to the fact that it damages body tissues and hampers the body's ability to repair this damage [4].

Amphetamine is a stimulant that speeds up the central nervous system, often used to treat ADHD. Users experience heightened alertness, energy, and concentration. However, it can also induce adverse effects like nervousness, rapid heartbeat, and can contribute to severe psychological issues if abused.

This is the most crucial rule to follow! When you use stimulants, they will temporarily hijack your dopamine reward system. Once the peak euphoria starts to fade, you will have a biological response to crave more. This is the same system that makes you crave food, sex, and anything pleasurable in life and is extremely hard to fight against. This feeling tends to disappear as soon as you have fully come down around the 10-12 hour mark (and in fact the thought of redosing actually starts to feel kinda gross). You simply need to endure through a few hours of cravings and then you’re home free. Not to mention that redosing will amplify your comedown side effects exponentially. It’s simply NOT worth it when you could just eat, sleep, and have an awesome time dosing the next morning instead.

Most stimulants suppress appetite heavily and its actually surprisingly easy to begin starving by accident during a long binge. In fact, many people are shocked to discover that the vast majority of the 24-hour comedown symptoms of meth and amphetamines are actually just a result of poor nutrition or hydration. What helps a lot is setting an alarm to go off on your phone every 2 hours from the moment you dose to remind you to eat and drink. It sounds silly, but when you’re peaking on stimulants you can easily get locked into whatever you’re doing, sometimes for hours or days. This alarm will shift your focus away from whatever you’re doing and provide an opportunity to break away and grab a snack with a glass of water. I know it’s easy to eat a ton of fruit and sweets while on stimulants, but please try to eat a variety of nutritious food instead. When all else fails, a big glass of milk is an excellent source of protein and nutrients.

Sometimes while using amphetamines you may encounter a horrible stench of ammonia that seems to soak into every piece of clothing. A lot of people think this is just due to excessive sweating, but it is actually a byproduct of rhabdomyolysis happening in your body and is a clear sign that you need to eat ASAP. When you take a stimulant that suppresses appetite you often don’t eat much (potentially for days) and so your body needs to look elsewhere for energy and nutrients. It does this by metabolizing your own muscles into protein, resulting in the loss of that muscle. The byproduct of this is ammonia, which is toxic to your body. As a result, your body tries to get rid of it as quick as possible, either through urine or sweat. This can also happen from dehydration as well, though eating usually gives your body some water as well. If you follow tip #2 you will notice that you don’t smell horrible at the end of the day (apart from the regular body odor that comes with sweating).

Most stimulants suppress appetite heavily. This doesn’t mean that your body suddenly doesn’t need food, its just temporarily unable to use the mesolimbic reward pathway to signal hunger in the way you typically recognize it. As a result, long binges or daily use can lead people down a dangerous road to starvation without even realizing it. If you find yourself in a situation like this, you need to pay attention to the other ways that your body is trying to signal to you that it desperately needs food. Often these signals can ‘seem’ like a need to redose, but this is misguided. If you suddenly find that your high has started to take a more anxious, numb, or unpleasant experience, this likely is a sign! 

These protein shakes may save your life! Each one contains around 360 calories and 25% daily value of most essential vitamins and minerals. They are shockingly easy to drink, even when you’re so high that it feels like you need to relearn how to swallow. If you are a daily user or prone to binges, you absolutely must keep these stocked in your fridge! If you find yourself in a situation like tip #3 and are unable to eat anything, these shakes just might prevent a trip to the hospital. Just make sure not to drink more than 3 in a day as they contain many fat soluble vitamins (Vit A, D, E, K) and you can definitely overdose on those. I would also avoid any multivitamins for 24 hours if you decide to drink a few of these shakes as that could also lead to vitamin overdose.

There is preclinical evidence that magnesium glycinate has the potential to block both sensitization and tolerance to stimulants. This is due to magnesium being an NMDA antagonist. It also replenishes an essential electrolyte that you brain uses for nearly every function, and which stimulants deplete heavily. In fact, did you know that 70% of Americans are already deficient in magnesium due to poor soil quality? The symptoms of deficiency are anxiety, depression, depersonalization, headache, and more!

If you notice vomiting, muscle aches, or blacking out while standing up, then grab a Gatorade or Powerade and chug it! Stimulants tend to deplete electrolytes faster than usual because of the strain they put on your body. Just be careful to not overdo it, as too many electrolytes can cause it's own problems.

Amphetamine has a habit of making you feel invincible and impulsive. In the moment you feel so confidence that the future really is of no concern to you… but this is an illusion… and pretty soon you’ll be dealing with the consequences while sober (gasp!). If you are about to make a big purchase, sign a contract, propose, or any other big decision, you should really just save it for the next morning no matter how confident you feel about it. And when selecting sexual partners ALWAYS use protection and ask yourself if you would actually have sex with this person if you were sober.

Amphetamine

Amphetamines are potent neurostimulants, increasing the levels of certain neurotransmitters like dopamine and norepinephrine in the brain. This can lead to short-term neurological effects like insomnia, restlessness, and hyperactivity. Long-term use can cause more severe neurological effects such as memory problems, cognitive deficits, and the development of a severe condition called amphetamine psychosis, which includes symptoms like paranoia, hallucinations, and delusions.

The rewarding effects of amphetamines make them highly addictive. Regular use can lead to physical and psychological dependence, where the user requires increasing amounts to achieve the same effects (tolerance) and experiences uncomfortable withdrawal symptoms when not using. Addiction to amphetamines can severely impact an individual's personal and professional life, often leading to social, financial, and legal problems.

Regular amphetamine use can cause a range of physical health problems, including malnutrition due to suppressed appetite, dental problems ('meth mouth'), skin sores from intense itching and scratching, and weight loss. In extreme cases, amphetamine abuse can lead to hyperthermia (dangerously high body temperature) and convulsions, which can be fatal if not treated promptly.

Amphetamine use, particularly in high doses or during binge episodes, can lead to impaired judgment and increased impulsivity, leading to risky behaviors such as unprotected sex, driving under the influence, or aggressive behavior. This can result in negative social and legal consequences, such as damaged relationships, job loss, and legal trouble.

Amphetamines have a profound effect on the cardiovascular system. They can elevate heart rate, blood pressure, and disrupt heart rhythm, which may lead to serious conditions such as hypertension, myocardial infarction (heart attack), stroke, and in severe cases, sudden death. Chronic use can lead to cardiovascular disease and cardiac arrest due to the sustained stress on the heart and blood vessels.

Fentanyl Strip

Marquis

Mecke

Simon

Benzodiazepines are a class of prescription drugs which usually come in the form of tablets. They are primarily used to treat anxiety and insomnia due to their depressant effect. Recreational users typically take benzos for their euphoric, relaxant and sedative effects.

Given the prevalence of counterfeit pills, it's crucial that users test their benzodiazepines before consumption. Fake pills can contain varying concentrations of the intended substance, or worse, include other potentially harmful substances. Pill testing kits, readily available online, allow users to determine whether their pills are genuine. These kits test for the presence of common benzodiazepines and may help identify pills that contain hazardous adulterants. With increasing reports of fentanyl laced benzodiazepines, it is absolutely crucial that you test every dose you intend to consume with a fentanyl strip.

Combining benzodiazepines with other central nervous system depressants, such as alcohol or opioids, can increase the risk of adverse effects and overdose. These substances can have synergistic effects, intensifying each other’s impacts and increasing the likelihood of dangerous outcomes like respiratory depression, unconsciousness, and even death. Always inform your healthcare provider about any other substances you're taking to avoid dangerous drug interactions.

Using high doses of benzodiazepines often results in memory loss. In fact, part of the reason people that combine benzodiazepines and alcohol end up overdosing is because they forget that they already took them and take more. By writing out a dosing regimen and having it clearly posted nearby, you can keep track of what you have already taken even if you experience memory loss. This could save your life!

Mixing benzodiazepines with stimulants like cocaine or amphetamines can create a dangerous combination. Stimulants can mask the sedative effects of benzodiazepines, potentially leading users to take more of the depressant drug than intended, increasing the risk of overdose. Additionally, this combination can place a significant strain on the heart and the nervous system, leading to complications such as cardiac arrest or seizures.

Injecting benzodiazepines can result in severe complications, including vein damage, skin and soft tissue infections, and increased risk of overdose. Many benzodiazepines are not formulated for injection, so this route can also lead to the injection of insoluble particles, which can cause blockages in blood vessels, potentially leading to serious organ damage. Non-injectable routes of administration are significantly safer and should be used instead.

Genetic factors can play a role in how individuals metabolize drugs, including benzodiazepines. Some people of Asian descent have genetic variations that can cause slower metabolism of certain benzodiazepines, leading to increased sensitivity and a higher risk of side effects. Healthcare providers should be aware of these potential differences when prescribing benzodiazepines to ensure that all patients receive a safe and effective dose.

Benzodiazepines

The occasional use of benzodiazepines has a relatively low risk of harm. However, when used longer than 3-4 weeks, dependence is likely to develop and stopping the drug suddenly causes withdrawal symptoms. Therefore, it is best not to take benzodiazepines for more than 1-2 weeks. Withdrawal symptoms can be a major problem, causing panic attacks, insomnia, irritability, aggression, palpitations, nausea, depression and muscle pain. In severe cases, withdrawal can even cause seizure, hallucination, and death. If you are dependent on benzodiazepines and are thinking of quitting, it is important to be under a doctor’s supervision to ensure your safety.

Benzodiazepines are often prescribed for anxiety, however, they do NOT have antidepressant effects with the possible exception of alprazolam. In fact, benzodiazepines might exacerbate depression and cause suicidal behavior and ideation since they depress the central nervous system. If you already struggle with depression, you should stay away from benzodiazepines to avoid exacerbating your condition.

Mandelin

Cannabis is a psychoactive drug from the cannabis plant used both medicinally and recreationally. It is smoked or ingested and users report feeling relaxed, happy, and hungry, along with pain relief. This comes at the risk of potential anxiety, paranoia, mild hallucination or even psychosis. There are many strains of Cannabis and each may significantly change the experience.

Edibles have a tendency to sneak up on you. It can sometimes take up to 3 hours to feel the full effects of a recently ingested edible. That being said, you don’t want to prematurely redose only to end up being way higher than you expected. Always be patient with edibles and wait at least 2 hours before you consider redosing.

Cannabis

Cannabis use during adolescence, a critical period for brain development, presents a substantial risk for neurotoxic effects. THC, the primary psychoactive component in cannabis, interacts with the endocannabinoid system, which plays a significant role in the development and function of various brain regions. Research suggests that early, regular, and heavy cannabis use can disrupt normal neurodevelopmental processes, potentially leading to long-lasting cognitive deficits. This could impact functions like memory, attention, processing speed, and executive functions like decision-making. Given that the brain continues to develop into the mid-twenties, these risks are not limited to younger teenagers but also apply to young adults.

Long-term use of cannabis is associated with an increased risk of depression. Though the precise mechanisms remain under study, it is thought that chronic cannabis use may lead to alterations in various neurological processes, including neurotransmitter function and neural connectivity. Over time, these changes could contribute to depressive symptoms or make an individual more susceptible to developing a depressive disorder. This risk may be higher in individuals with a genetic predisposition to depression or those who began using cannabis at a young age. Additionally, the relationship between cannabis and depression may be bidirectional, with depression potentially leading to increased cannabis use, and vice versa, creating a vicious cycle that can be difficult to break.

Duquenois-Levine

Cocaine is a powerful stimulant drug, derived from the coca plant, predominantly used for recreational purposes. It affects the central nervous system, heightening alertness, increasing energy, and creating feelings of euphoria. Long-term usage can lead to serious heart health issues.

Grinding your cocaine can remove clumps. This will prevent you from accidentally snorting too much as each line will be more consistent.

Cocaine is cardiotoxic and over time rapidly increases the chances of suffering a heart attack. If you already suffer from pre-existing heart or cardiovascular disease, you should stay away from cocaine as it could trigger a heart attack after just a few uses.

Cocaine

Chronic redosing, or the repeated administration of cocaine within a short time frame, significantly amplifies the risk of adverse effects and overdose. As the euphoric effects of cocaine are brief, users might be tempted to redose to prolong the experience. However, this practice increases the concentration of the drug in the system, potentially leading to dangerous levels of stimulation for the cardiovascular and nervous systems. Harm reduction strategies here should focus on setting strict limits on usage and allowing sufficient time for the drug to metabolize and exit the system before considering redosing.

Cocaine can significantly alter a user's judgment, leading to impulsive, risky, or even aggressive behavior. The drug often induces a sense of inflated self-confidence and invulnerability, which can contribute to accidents, unsafe sexual practices, or conflicts with others. If one chooses to use cocaine, it's crucial to be in a safe, familiar environment with trustworthy people around. Having a sober, reliable friend present can also help manage potentially dangerous situations.

Cocaine use places a substantial burden on the cardiovascular system, causing elevated heart rate and blood pressure. Over time, or even during a single intense use, these changes can contribute to severe problems like heart attack, stroke, and irregular heart rhythms. People with pre-existing heart conditions are at an especially high risk. Harm reduction for cardiovascular health involves limiting the quantity and frequency of cocaine use, maintaining overall health and fitness, and seeking immediate medical attention for symptoms like chest pain or shortness of breath after using the drug.

Street cocaine is often cut with various substitutes and adulterants to increase profits. Some of these substances, such as levamisole, can have harmful or even life-threatening effects. Using a reagent testing kit can help identify some adulterants, but it's not infallible. To reduce harm, users should buy from trustworthy sources, be wary of unusually cheap or high-purity offerings, and use a testing kit whenever possible.

Liebermann

Ketamine is a hallucinogenic dissociative and anaesthetic that is used in both humans and animals for medical purposes. In low doses, users report a similar feeling to being drunk. Higher doses cause a much more dissociative or psychedelic effect.

Nausea and vomiting can occur when coming up on Ketamine. You can usually avoid this by not eating any food 1.5 hours before dosing.

Ketamine

Chronic use of ketamine can lead to significant urinary problems, such as ketamine-induced cystitis, a painful bladder syndrome. This may manifest as an increase in frequency and urgency of urination, discomfort during urination, and in severe cases, blood in the urine. To minimize these risks, it's crucial to moderate ketamine use and maintain good hydration. Regular monitoring of urinary symptoms is important, and users should seek medical attention if any issues arise. If you're using ketamine regularly and begin to notice these symptoms, it's advisable to reduce use or stop altogether, and consult with a healthcare provider.

Ketamine is known to have profound effects on memory. Long-term, heavy use can potentially lead to memory impairments, particularly affecting episodic (autobiographical) and working (short-term) memory. This could interfere with daily life activities, relationships, and occupational functioning. To reduce this risk, limit use to moderate levels and ensure periods of abstinence to allow the brain time to recover. Cognitive exercises and a healthy lifestyle, including a balanced diet, regular exercise, and adequate sleep, may also be beneficial. Should you notice memory issues or cognitive difficulties, it's recommended to seek medical advice and consider discontinuing ketamine use.

Morris

Kratom, or Mitragyna speciosa, is a tropical tree belonging to the coffee family that’s been used in traditional medicine since the 19th century. It’s a diverse drug that produces a different high depending on the dosage: at a low dose it has stimulatory effects, whereas at higher doses, opioid-like sedative and euphoric effects occur.

Kratom can cause dehydration in users. It's important to ensure you are drinking adequate water when using Kratom to avoid dehydration.

Kratom dependence and withdrawl is not joke when it comes to long term use. Daily users that have quit have likened the withdrawals to that of serious opioid withdrawal like oxycodone and even heroin. By limiting your Kratom usage, you can still enjoy the substance in moderation while avoiding withdrawals.

Kratom

Whilst Kratom is not thought to have a strong dependency potential, especially when taken at low doses, when you take something regularly a habitual addiction can form. With a habitual addiction comes an increasing tolerance that demands bigger doses. When used consistently, Kratom is known to cause severe withdrawal symptoms on par with opioid withdrawal from substances like oxycodone and even heroin. We recommend that you monitor your Kratom use and limit yourself to no more than one dose every 3 days to avoid having to suffer through withdrawals.

Studies of frequent kratom users in Thailand and Malaysia have suggested the existence of long-term side effects associated with the use of high doses of kratom for a prolonged period of time. These include weight loss, nausea, insomnia, fatigue, constipation, seizures, psychosis, and more. It’s also important to consider that very little research has been done on Kratom, and thus we are not fully aware of it’s safety profile. We recommend monitoring your Kratom use and limiting yourself to no more than one dose every 3 days to avoid any potentially debilitating symptoms.

LSD (Lysergic Acid Diethylamide) is a synthetic hallucinogenic drug that induces altered states of perception and feelings, causing hallucinations, distorted visual perception of shapes and colors, and altered sounds. The effects are long lasting and can lead to powerful spiritual and psychological experiences.

When it comes to the use of LSD, the concept of "set and setting" is essential for reducing the risk of a negative experience or "bad trip". "Set" refers to one's mindset, including their current emotional state, expectations, and general disposition toward the experience. A positive mindset can greatly influence the direction of the trip. "Setting", on the other hand, refers to the physical and social environment where the drug is taken. A safe, comfortable, and familiar environment can provide a positive framework for the experience and help prevent feelings of anxiety or paranoia. It's also recommended to clear your schedule for the day of the trip and the following day to allow time for reflection and rest without the pressure of obligations.

A trip sitter is a sober individual who stays with you while you're under the influence of a psychedelic like LSD. This person is there to ensure your safety, provide reassurance, and assist with practical matters. Having a trip sitter, especially for those new to psychedelics or taking a higher dose, can significantly reduce the risk of harm and help manage any anxiety or discomfort that may arise during the trip. A good trip sitter should be someone you trust, who is familiar with the effects of the drug, and who can remain calm and supportive in various situations. The presence of a trip sitter can provide an extra layer of security, helping to ensure that the experience remains positive and safe.

Hallucinogen Persisting Perception Disorder (HPPD) is a condition characterized by a continual presence of sensory disturbances, most often visual, that are reminiscent of those generated while one was under the influence of a psychedelic or hallucinogenic substance such as LSD. Individuals with HPPD might experience symptoms like trailing images, visual snow, halos, or intense colors, among others. These disturbances can last for months or even years after cessation of drug use and can be distressing, leading to impairment in social or occupational functioning. The exact cause of HPPD is not known, but it is believed to be associated with changes in neuronal excitability in the central nervous system. While relatively rare, the risk of developing HPPD can be increased with heavier or more frequent use of hallucinogens. It's also important to note that while HPPD can be distressing, it is not associated with brain damage and can often be managed with professional help. If you suspect you might have HPPD, it's important to seek professional medical advice.

Ehrlich

Hoffman

MDMA, also known as ecstasy or molly, is a synthetic drug that alters mood and perception. It is commonly used for recreational purposes, producing feelings of euphoria, increased energy, and empathy towards others. Ecstasy is a tablet form often mixed with other drugs.

There is a common misconception that MDMA must be done at a rave or music festival to be enjoyed. Like all drugs, MDMA affects people differently based on a number of factors, and it can be risky trying it for the first time in a foreign or dangerous environment like a rave. While on MDMA you will experience increased empathy and suggestibility, making it easy for strangers to take advantage of you. For this reason, we HIGHLY recommend trying MDMA at home with friends or a loved one. You will still have a great time and will be able to better gauge how you respond to the drug incase you decide to use in a riskier environment in the future. 

MDMA is linked to water toxicity deaths due to the tendency for users to drink excessive amounts of water. This is likely due to a combination of the increased body temperature caused by the drug and the high-energy activities many users engage in while on the drug (rave, festival, club, etc). On the other hand, it’s also important to make sure you don’t get dehydrated. We recommend setting alarms to go off every hour for a glass of water. This way you will be hydrating consistently but never need to guess if you’ve had too much.

MDMA is much more neurotoxic than most drugs because of some key metabolites that end up causing lots of free radical damage in your brain. It has been shown that using a number of supplements before, during, and after MDMA use can not only prevent neurotoxic damage to the brain, but also drastically reduce the comedown. We recommend checking out RollKit, which is a company that sells individual supplement packages for each MDMA roll. This will make it easy for you to keep track of what you have taken and save you the trouble of having to research what supplements are best to take. Check them out here: https://rollkit.net/

MDMA

MDMA use can increase the risk of dehydration or hyperhydration. MDMA raises body temperature and can lead to fluid imbalances. Activities like dancing at music festivals or clubs, often accompanied by MDMA use, can further contribute to dehydration. On the other hand, excessive water consumption can lead to hyponatremia, a condition where the body's electrolyte balance is disrupted. To mitigate these risks, it's important to stay adequately hydrated without overdoing it. Drink water in moderation, take breaks from physical activity, and be mindful of the body's fluid needs. Seek shade or cool environments to regulate body temperature.

Prolonged or excessive MDMA use may increase the risk of neurotoxicity, which can cause damage to nerve cells in the brain. Studies suggest that MDMA use can lead to long-term changes in the serotonin system, potentially resulting in cognitive impairments, memory deficits, and mood disturbances. To minimize the potential for neurotoxic effects, use MDMA no more than once every three months. This will give your brain’s receptors adequate time to restore their supply of serotonin.

Heatstroke is a severe condition that can occur when using MDMA, particularly in hot environments or during intense physical activity. MDMA raises body temperature, impairing the body's temperature regulation. This, combined with factors like inadequate hydration and prolonged dancing, can lead to heatstroke. Symptoms include a body temperature above 40°C (104°F), rapid heartbeat, headache, dizziness, confusion, nausea, and loss of consciousness. To prevent heatstroke, stay hydrated, take breaks in cooler environments, wear appropriate clothing, and be aware of signs of overheating. Seek prompt medical attention if heatstroke is suspected.

Methamphetamine is a powerful, highly addictive stimulant that speeds up the central nervous system. It takes the form of a white, odorless, bitter-tasting crystalline powder that easily dissolves in water or alcohol. It is smoked, ingested, or snorted and users report feeling energized, confident, and euphoric but associated with anxiety, paranoia, hyperactivity, and even psychosis.

Sometimes while using meth you may encounter a horrible stench of ammonia that seems to soak into every piece of clothing. A lot of people think this is just due to excessive sweating, but it is actually a byproduct of rhabdomyolysis happening in your body and is a clear sign that you need to eat ASAP. When you take a stimulant that suppresses appetite you often don’t eat much (potentially for days) and so your body needs to look elsewhere for energy and nutrients. It does this by metabolizing your own muscles into protein, resulting in the loss of that muscle. The byproduct of this is ammonia, which is toxic to your body. As a result, your body tries to get rid of it as quick as possible, either through urine or sweat. This can also happen from dehydration as well, though eating usually gives your body some water as well. If you follow tip #2 you will notice that you don’t smell horrible at the end of the day (apart from the regular body odor that comes with sweating).

Methamphetamine has a habit of making you feel invincible and impulsive. In the moment you feel so confidence that the future really is of no concern to you… but this is an illusion… and pretty soon you’ll be dealing with the consequences while sober (gasp!). If you are about to make a big purchase, sign a contract, propose, or any other big decision, you should really just save it for the next morning no matter how confident you feel about it. And when selecting sexual partners ALWAYS use protection and ask yourself if you would actually have sex with this person if you were sober.

Methamphetamine

A fatal overdose from methamphetamine typically occurs due to the drug's intense stimulant effect on the cardiovascular system, leading to heart failure or stroke [4]. High doses can dramatically increase heart rate and blood pressure, potentially causing heart arrhythmia, acute heart damage, or a sudden increase in blood pressure that can result in a hemorrhagic stroke [5]. Overdose can also lead to hyperthermia or severe seizures [6]. Because methamphetamine is often used in a binge pattern, the risk of fatal overdose increases with each additional dose [7]. Recognizing signs of an overdose, such as chest pain, extreme agitation, or seizures, and seeking immediate medical attention can save lives [8].

Methamphetamine is neurotoxic, meaning it can cause significant damage to brain cells [9]. It does so primarily by increasing the release and blocking the reuptake of the neurotransmitter dopamine, leading to high levels in the brain [10]. Over time, this can cause damage to the neurons that produce and use dopamine, leading to long-term cognitive deficits [11]. Symptoms of this neurotoxicity can include impairments in memory, attention, and decision-making, and motor coordination. In severe cases, it can result in symptoms similar to Parkinson's disease [12]. The neurotoxic effects of methamphetamine can persist even after discontinuation of the drug, highlighting the importance of harm reduction strategies and treatment interventions [13].

Methamphetamine-induced psychosis is a severe mental health risk associated with methamphetamine use. It can manifest as hallucinations, delusions, and extreme paranoia [14]. This happens due to the drug's profound effect on dopamine, a neurotransmitter heavily involved in our perception of reality and response to external stimuli [15]. High levels of dopamine can distort these processes, leading to psychotic symptoms [16]. These symptoms can persist even after discontinuation of methamphetamine and may require treatment with antipsychotic medications [17]. It's worth noting that individuals with pre-existing susceptibility to psychotic disorders are at a particularly high risk of experiencing psychosis with methamphetamine use [18].

Magic Mushrooms, also known as Psilocybin Mushrooms, contain the psychoactive compound psilocybin, which causes hallucinations, perception changes, and a sense of heightened understanding or euphoria. The effects vary widely and typically last from four to six hours, depending on the dosage and individual's metabolism.

When it comes to the use of magic mushrooms, the concept of "set and setting" is essential for reducing the risk of a negative experience or "bad trip". "Set" refers to one's mindset, including their current emotional state, expectations, and general disposition toward the experience. A positive mindset can greatly influence the direction of the trip. "Setting", on the other hand, refers to the physical and social environment where the drug is taken. A safe, comfortable, and familiar environment can provide a positive framework for the experience and help prevent feelings of anxiety or paranoia. It's also recommended to clear your schedule for the day of the trip and the following day to allow time for reflection and rest without the pressure of obligations.

A trip sitter is a sober individual who stays with you while you're under the influence of a psychedelic like magic mushrooms. This person is there to ensure your safety, provide reassurance, and assist with practical matters. Having a trip sitter, especially for those new to psychedelics or taking a higher dose, can significantly reduce the risk of harm and help manage any anxiety or discomfort that may arise during the trip. A good trip sitter should be someone you trust, who is familiar with the effects of the drug, and who can remain calm and supportive in various situations. The presence of a trip sitter can provide an extra layer of security, helping to ensure that the experience remains positive and safe.

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